Identification of novel human cancer-specific antigens Literature review

Identification of novel human cancer-specific antigens - Literature review voice Likewise, opportunities to develop cancer treatment demonstrated promising results (Haffner et al., 2001 Jager, Jager, and Knuth, 2002 Fijak and Meinhardt, 2006 Park, Lin, Nishidate, Nakamura & Katagiri, 2006 Tabi and Man, 2006 Hayashi et al., 2007 Meklat et al., 2007 Dakshinamurthy, Ramesar, Goldberg and Blackburn, 2008 Hunder et al., 2008 Old, 2008 Caballero and Chen, 2009 Chen et al., 2009 Dubovsky et al., 2009 Fard and Modaressi, 2009 Vujanovic and Butterfield, 2009). Consequently, pioneering research in the search for effective cancer vaccines has produced cancer/testis antigens such(prenominal) as MAGE, GAGE, and NY-ESO-1 which are currently undergoing clinical trials (Mashino et al. 2001 Bowlus, 2007 Gierstoff and Ditzel, 2008). Each year more cancer/testis antigens are being identified, creating more opportunities for research and increasing the chances of develop cancer vaccines that can be us ed not only for treatments, unless for prevention as well (Jager, Jager, and Knuth, 2002). Also, research on cancer/testis antigens has brought to abstemious important discoveries on how mechanisms of cancer development work at a molecular level (Alters, 2000 Old, 2001 Gjerstoff, Kock, Nielsen and Ditzel, 2007 Delbridge, 2010 Inagaki, Schoenmakers and Baarends, 2010 Suzuki et al., 2010). Moreover, studies on the link between chromo almosts and immune responses reveal that some cancers are more prevalent in males than in females. In addition, results also show that females may have higher cancer survival rates but are more susceptible to autoimmune diseases (Libert, Dejager and Pinheiro, 2010). Further research on the role of cancer/testis antigens should be conducted, particularly in determining the mechanisms that go cancer in the first place. Also, further studies should be performed to developed better cancer diagnostic methods and combination immunotherapy